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I know we can connect 4 ADS1115s to an Arduino Mega 2560.

Is there any limit on the number of ADS1115s we can connect to the Mega giving each a different address? I have to connect at least 36 ADS1115s.

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  • you could try connecting all 36 ... pull one of 36 address lines high and talk to that one selected device
    – jsotola
    Dec 20, 2021 at 15:25

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256(+?)

With 8 TCA9548A 1-to-8 I2C Multiplexers on different I2C addresses, it is a multiplication problem: You can expand the Arduino Mega's I2C port on Digital Pins 20&21 to 8 multiplexers * 8 multiplexer ports * 8 ADS1115 addresses to 256.

It might be possible to go much further if you can wire and code multiple levels of multiplexers.

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